Thursday Night Football odds, spread, line: Seahawks vs. 49ers prediction, NFL pick by expert on 19-6 run

The Seattle Seahawks will be looking to stay alive in the NFC West title chase when they host rival San Francisco 49ers on Thursday Night Football. After dropping three of their last four games to lose the division lead, the Seahawks (7-6) need a win to avoid being knocked out of the division title. A win would also help their wild card hopes as they enter Week 15 behind the Commanders and Giants (both 7-5-1) for the final spot in the NFL playoff picture. Meanwhile, the 49ers (9-4) can become the first NFL team to clinch a split this season with a win over TNF.

Kickoff is scheduled for 8:15 p.m. ET. San Francisco is a three-point favorite in Caesars Sportsbook’s latest Seahawks vs. 49ers odds, while the over/under for total runs scored is 43. Before you make any 49ers vs. Seahawks picks or NFL predictions, you’ll want to see what SportsLine’s resident Seahawks pundit Josh Nagel has to say.

Nagel is a Nevada-based handicapper with over 20 years experience in the sports betting industry. The SportsLine Associate Editor has covered the betting industry on a variety of platforms and has won numerous sports handicap competitions. He’s hit 54% of his NFL picks against the spread (749-636-22) since the start of the 2016 season.

Additionally, Nagel is 19-6 in his last 25 spread picks involving the Seahawks. Everyone who followed him is upstairs.

Now Nagel has focused on Seahawks vs. 49ers and has just locked in his TNF picks and predictions. You can head over to SportsLine to see Nagel’s picks. Now, here are several NFL odds and betting lines for the Niners. against Seahawks:

  • Difference Seahawks vs. 49ers: San Francisco -3
  • Seahawks vs. 49ers over/under: 43 points
  • 49ers money line vs. Seahawks: San Francisco -180, Seattle +150
  • SF: The 49ers lead the league in defense (15.2 points per game).
  • SEA: LB Jordyn Brooks ranks second in the NFL in tackles (141).
  • Seahawks pick vs. 49ers: See picks on SportsLine

Featured Game | Seattle Seahawks vs. San Francisco 49ers

Why the 49ers can cover

The San Francisco passers have a positive game against the Seattle defense. The 49ers are averaging 6.45 yards after the catch this season, which ranks them third in the league. Meanwhile, the Seahawks are giving up 5.95 yards after the catch, which is second-worst in the NFL.

Also, the last time Seattle quarterback Geno Smith faced San Francisco, he had his worst performance of the season. In Week 2, he had no touchdown passes and one interception, his worst touchdown-to-interception ratio of the year. He also had the season’s worst passer rating (80.1) and second-lowest passing yardage total (197). See which team to choose here.

Why the Seahawks can cover

Seattle has a three-headed monster at receiver in DK Metcalf, Tyler Lockett and Marquise Goodwin. Metcalf has scored a touchdown in four of the last six games. Lockett has scored a touchdown in the last six games, the longest streak in franchise history. Goodwin is coming off arguably his best game of the season (five catches, 95 yards and a touchdown) against the Panthers.

Also, the Seahawks defense did a great job against Carolina quarterback Sam Darnold last week. Seattle limited the Panthers flagger to just 120 passing yards and 5.0 yards per attempt. Its longest completion was only 18 meters. See which team to choose here.

How to make Seahawks vs. 49ers picks

We can tell you that Nagel is looking at total points, but he’s also isolated a critical X-factor that’s making him bigger on one side of the gap. He’s just sharing what it is, and which side to support, at SportsLine.

Who wins the Seahawks against the 49ers at Thursday Night Football? And what critical X-factor causes one side of the spread to be hit hard? Visit SportsLine now to see which way the 49ers vs. the Seahawks spread, all from the expert who is 19-6 over his last 25 picks against the spread involving Seattle, and find out.

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